Knoxville is a city in Knox County, Tennessee, United States, and its county seat. It is located on the Tennessee River and had a populatio…Knoxville is a city in Knox County, Tennessee, United States, and its county seat. It is located on the Tennessee River and had a population of 190,740 at the 2020 United States census. It is the largest city in the East Tennessee Grand Division and the state's third-most populous city, after Nashville and Memphis. It is the principal city of the Knoxville metropolitan area, which had a population of 879,773 in 2020.
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