Head writer Jeff Trammell and supervising director Mel Zwyer pay homage to the early comics with a "moving comic" style in CG while introducing a surprising supporting cast.

Your Friendly Neighborhood Spider-Man doesn’t spin the same old origin story. Marvel Studios’ first Spider-Man animated series was conceived as a prequel to the live-action films starring Tom Holland,

But the most similar origin story to the one shown in Your Friendly Neighborhood Spider-Man is actually that of Miles Morales in Spider-Man: Into the Spider-Verse, where he’s bitten by a spider from a different dimension.