Iran's Supreme Leader Ayatollah Ali Khamenei said on Wednesday that abandoning uranium enrichment was "100%" against the country's interests, rejecting a central U.S. demand in talks to resolve a decades-long dispute over Tehran's nuclear ambitions.

Iran's supreme leader on Wednesday dismissed US calls for Tehran to stop enriching uranium. "The key to nuclear technology is uranium enrichment, and our enemies want to prevent precisely this in order to undermine our independence and our scientific potential,

Iran’s Supreme Leader Ayatollah Ali Khamenei rejected on Wednesday US calls to halt nuclear enrichment, saying the process is central to the country’s nuclear program.