Japan's Osaka looked every bit the Grand Slam great for a set before losing 3-6 6-4 6-4 to Russia's Anastasia Pavlyuchenkova. American Keys racked up 31 unforced errors in a 6-3 6-3 loss to Germany's Laura Siegemund, at 37 the oldest woman left in the singles draw.

Carlos Alcaraz's charge towards a third consecutive Wimbledon crown faces a tricky test against volatile Russian Andrey Rublev on Sunday. "You cannot show any weaknesses," said Rublev on the challenge of facing Alcaraz.

Carlos Alcaraz battled past Jan-Lennard Struff to reach the Wimbledon last-16 on Friday before women's top seed Aryna Sabalenka dug deep to beat Emma Raducanu in a high-class match.