A study by the Josep Carreras Leukaemia Research Institute reveals a mechanism that controls B-lymphocyte maturation, with SIRT7 playing a critical role. This insight could lead to new treatments for ...

T-cell acute lymphoblastic leukemia (T-ALL) is a highly aggressive form of blood cancer that can occur in both children and ...

Helix–loop–helix (HLH) proteins are essential factors for lymphocyte development and function. One class of HLH proteins, the E-proteins, regulate many aspects of lymphocyte maturation ...

During lymphocyte maturation, each B cell and T cell acquires specific cell membrane surface receptors that allow them to "match up" with certain foreign antigens.

Researchers from the Chromatin Biology lab at the Josep Carreras Leukaemia Research Institute just discovered a fundamental mechanism controlling B-lymphocyte maturation in the bone marrow.

The normal thymus contains only a very small number of γ/δ T cells, and these cells constitute up to 5 percent of circulating lymphocytes. 18 The thymocytes from Patient 1 contained increased ...

Calcium plays an essential role in lymphocyte activation and maturation but the exact effect on gene expression is not known. In April Nature Immunology Stefan Feske and colleagues from Harvard ...

The thymus plays a key role in the body's immune response. It is here where the T lymphocytes or T cells, a major type of immune defence cells, mature. Different types of T cells, designated to ...

Interleukin-12 (IL-12) is a pleiotropic cytokine designated as a cytotoxic lymphocyte maturation factor and NK cell stimulator that interconnects innate and adaptive immunity. Studies in animal models ...

To fight off viral and bacterial invaders, immune cells known as lymphocytes generate antibodies that specifically recognize and bind to these invaders, neutralizing them directly or marking them ...

A study by the Josep Carreras Leukaemia Research Institute reveals a mechanism that controls B-lymphocyte maturation, with SIRT7 playing a critical role. This insight could lead to new treatments for ...