Selectively inactivating a molecular switch that turns on the gene Nr4a1 in monocytes but not macrophages leads to the loss of patrolling monocytes, which play an important role in suppressing ...

and fungi Release chemicals to activate an immune response in the affected area Monocytes also become macrophages, which contain chemicals that directly destroy disease-causing infectious organisms.

now report that the deletion of two transcription factors linked to monocyte differentiation could confer limitless self-renewal capacity to mature differentiated macrophages. Surprisingly ...

In this application note, explore how scientists can couple a serum-free medium with a xeno-free serum replacement to effectively culture functional monocyte-derived dendritic cells and macrophages.

For example, it was possible to show that different clusters in fact represent the same inflammatory synovial macrophage subset, and are transcriptionally similar to an IL1B+ monocyte subset ...

(A) Volcano plot of DEGs in monocytes/macrophages between NC and CRC samples in the GSE164552 dataset. (B) Venn diagrams of common DEGs up- or down-regulated across the six scRNA-seq datasets (NC vs.

Over the past ten years, we have investigated the developmental origin and homeostasis of macrophages and the related cell types monocytes and dendritic cells. These cells play a major role in diverse ...