Bones are constantly being remodeled through the action of osteoclasts ... to induce or enhance specific cellular functions," says the co-senior author of the study, Takao Nakata.

Organ cultures of newborn mouse calvaria were used to test the hypothesis that tartrate-resistant acid phosphatase might serve as a biochemical marker for osteoclast function. When bone resorption ...

Prof. Hayata says, “RANKL functions as an ‘accelerator’ for osteoclast cell differentiation. Driving a car requires not only the accelerator but also the brakes. Here, we find that Ctdnep1 f ...

Immunomodulatory agents alter abnormal bone metabolism in MM, inhibiting osteoclast function. Novel agents under evaluation, targeting the RANKL/OPG system and DKK-1, are expected to extend the ...

A study has identified three new genes that regulate osteoclasts and are implicated ... genetic variants are affecting the expression or function of these genes have not been performed.