Huntington, surprising mechanism

Surprise finding sheds light on what causes Huntington's disease, a devastating fatal brain disorder
Scientists are unraveling the mystery of what triggers Huntington’s disease, a devastating and fatal hereditary disorder that strikes in the prime of life, causing nerve cells in parts of the brain to break down and die.
New findings shed light on cause of Huntington's disease progression
A new study of nerve cells affected by Huntington’s disease (HD) reveals that the disease-causing gene slowly expands over time, but doesn't start causing harm until it hits a toxic threshold that rapidly leads to the nerve cell’s death.
Study finds surprising way that genetic mutation causes Huntington's disease, transforming understanding of the disorder
Scientists have discovered a surprising mechanism by which the inherited genetic mutation known to cause Huntington's disease leads to the death of brain cells. The findings change the understanding of the fatal neurodegenerative disorder and suggest potential ways to delay or even prevent it.
A better understanding of Huntington’s disease brings hope
But Huntington’s second, self-preserving, oddity is that unlike most genetic disorders it rarely manifests until well into adulthood, giving plenty of time for it to be passed on. The result is families where half the members are living under premature death sentences.
New Research Sheds Light on the Causes of Huntington’s Disease
If you’ve ever heard of Huntington’s disease, you know how devastating it can be. This hereditary brain disorder slowly robs people of their ability to think, move, and even communicate. The disease’s progression is relentless,
Medical mystery solved: Why do some people develop Huntington's earlier than others?
New genetic research shows why some people develop deadly Huntington's disease earlier than others. The findings could lead ...
Science Daily4h
Brain changes in Huntington's disease decades before diagnosis will guide future prevention trials
Subtle changes in the brain, detectable through advanced imaging, blood and spinal fluid analysis, happen approximately twenty years before a clinical motor diagnosis in people with Huntington's ...
Harvard Medical School2d
New Understanding of How Genetic Mutation Causes Huntington’s Disease
Study explains long-standing question of why Huntington’s disease symptoms typically do not appear until midlife even though ...
Experts hail 'milestone' in study of the deadly Huntington's disease
About 2,000 people in Australia are affected by Huntington's disease, a fatal and incurable condition that affects the ...
BioWorld1d
Huntington’s neurodegeneration starts at 150 repeat expansions
Having 35 copies of the CAG triplet in the gene that causes Huntington’s disease is not a problem. Inheriting 40 could be a ...
Nature2d
Revealed: Why the fatal Huntington’s gene takes so long to cause harm
Huntington’s is an incurable and fatal genetic condition that progressively affects movement, balance and cognition. It is ...
News Medical on MSN1d
Early brain changes in Huntington’s disease detected two decades before symptoms
Subtle changes in the brain, detectable through advanced imaging, blood and spinal fluid analysis, happen approximately twenty years before a clinical motor diagnosis in people with Huntington's ...
Oneindia2d
New Research Uncovers Delayed Effects of Genetic Mutation in Huntington's Disease Development
Recent findings uncover how Huntington's disease develops over time, revealing the mutation's delayed effects on brain cells.
STAT2d
Studies reveal a new biology of Huntington’s, renewing drugmaker interest in therapies
A new study highlights the potential of a therapeutic strategy focused on stopping or slowing Huntington's disease.