Researchers from Bonn and Erlangen identify the protein MLC1 as a target antigen in multiple sclerosis (MS); a chronic inflammatory disease of the central nervous system caused by the immune system.

They also observed significantly increased titers against MLC1 in the cerebrospinal fluid of patients with viral-induced neuroinflammatory diseases of the central nervous system.

In the brain section of an MS patient, the neurons are shown in green and the target antigen MLC1 in red. Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system ...

The MLC1 gene consists of 11 coding exons and a first non-coding exon. It encodes a 377-amino-acids plasma membrane protein with eight transmembrane domains and is highly conserved throughout ...

This rare disease is caused by mutations in MLC1 and GlialCAM and produces megalencephaly, spasticity and ataxia in humans. A new study describes a phenotype of this human disease through the ...

SIR – We appreciate the comments from Leegwater and colleagues regarding our recently published article about the possibility that the L309M variant of the KIAA0027 (WKL1, MLC1) gene may cause ...

In this research, a team led by Assumpció Bosch administered a viral vector carrying a healthy copy of the MLC1 gene to an animal model of the disease in order to restore normal protein activity. The ...

A recent study led by the Universitat Autònoma de Barcelona (UAB) demonstrates the potential of gene therapy to restore motor capacity in an ultra-rare disease, Megalencephalic ...

Researchers at the University Hospital Bonn (UKB), the University of Bonn and the FAU Erlangen-Nuremberg identified the membrane protein MLC1 as a potential target antigen in MS.