Researchers from Bonn and Erlangen identify the protein MLC1 as a target antigen in multiple sclerosis (MS); a chronic inflammatory disease of the central nervous system caused by the immune ...

Researchers at the University Hospital Bonn (UKB), the University of Bonn and the FAU Erlangen-Nuremberg identified the membrane protein MLC1 as a potential target antigen in MS.

In the brain section of an MS patient, the neurons are shown in green and the target antigen MLC1 in red. Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system ...

Conclusions state that the lack of MLC1 expression causes the delocalization of protein GlialCAM which mimics neuronal activity in all studied models.

The MLC1 protein is specifically expressed in distal processes of astrocytes called endfeet. 5, 6 This specific localization, the number of transmembrane domains, together with a weak ...

A recent study demonstrated the potential of gene therapy to restore motor capacity in an ultra-rare disease, megalencephalic leukoencephalopathy with subcortical cysts (MLC), even when treatment ...

More than 75% of diagnosed cases are caused by mutations in the MLC1 gene, which encodes a protein located in the membrane of a type of brain cell called astrocyte.