WASHINGTON (AP) — After a weekend of setbacks, the Senate will try to sprint ahead Monday on President Donald Trump’s big bill of tax breaks and spending cuts despite a series of challenges, including the sudden announcement from one GOP senator that he won’t run for reelection after opposing the package over its Medicaid health care cuts.

At some 940-pages, the legislation is a sprawling collection of tax breaks, spending cuts and other Republican priorities, including new money for national defense and deportations.