Scientists create method for designing proteins that can bind and sense a range of small molecules
From growth hormones to cancer drugs, small molecules play a crucial role in our health. Monitoring them is essential to ...
EurekAlert!6d
Breaking boundaries in biomedicine: Advanced Photon Source enables protein design
A team of scientists in the lab of Nobel Prize winner David Baker has created a method for designing proteins that can bind and sense a range of small molecules, with wide applications for biomedicine ...
eLife5d
Transcriptional Dynamics Uncover the Role of BNIP3 in Mitophagy during Muscle Remodeling in Drosophila
This paper presents the important finding that BNIP3/NIX, a mitophagy receptor, and its binding to ATG18 are required for mitophagy during muscle cell reorganization in Drosophila. Although the ...
eLife4d
Descending locus coeruleus noradrenergic signaling to spinal astrocyte subset is required for stress-induced pain facilitation
Here, we identified a circuit, locus coeruleus descending noradrenergic neurons projecting to the spinal dorsal horn (LC →SDH -NA neurons), that is activated by acute exposure to restraint stress and ...