Medically reviewed by Allison Herries, RDN Manganese is a trace mineral, meaning your body needs it in smaller amounts than ...

In most primary and metastatic malignant tumors, bone destruction can promote cancer progression, which is closely related to osteoclast activation and the imbalance between osteoblasts and ...

This article highlights the involvement of osteoclasts and osteoblasts in activating different mechanical transduction pathways and reports changings in their differentiation, formation, and ...

GSD’s pathogenesis is still unclear, but osteoclasts' activation may play a role in its pathogenesis. There are multiple complications associated with GSD. One of the most severe and life-threatening ...

Activation of the CaSR from increased ionised calcium leads ... and cytokines (tumour necrosis factor α (TNFα), interleukin 6 (IL-6), which increase osteoclast activity). Hypercalcaemia may be found ...

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We are interested in molecular mechanisms underlying neural development, neuro-degeneration, and bone homeostasis. Although neural development, neurodegeneration, and bone homeostasis are three ...

Objectives Metabolic changes are crucially involved in osteoclast development and may contribute to bone degradation in rheumatoid arthritis (RA). The enzyme aconitate decarboxylase 1 (Acod1) is known ...

In vitro, effects of L-arginine on osteoclast differentiation were analysed by RNA-seq and mass spectrometry (MS). Seahorse, Single Cell ENergetIc metabolism by profilIng Translation inHibition and ...