A new study in mice shows how the small GTPase Cdc42 influences bone modeling and remodeling—it modulates both the formation and function of osteoclasts, and is involved in the downstream ...

Prof. Hayata says, “RANKL functions as an ‘accelerator’ for osteoclast cell differentiation. Driving a car requires not only the accelerator but also the brakes. Here, we find that Ctdnep1 f ...

Organ cultures of newborn mouse calvaria were used to test the hypothesis that tartrate-resistant acid phosphatase might serve as a biochemical marker for osteoclast function. When bone resorption ...

A study has identified three new genes that regulate osteoclasts and are implicated ... genetic variants are affecting the expression or function of these genes have not been performed.