Upon activation by RTK, GPCR, Integrin, and Ras, p110 loses inhibition by p85 ... AKT regulates the cell cycle by phosphorylating FoxO1 and decreasing its transcription of CDK inhibitors p21 ...

Type 1 dendritic cells are key to initiate and maintain anti-tumoral T-cell responses in diverse tumour tissues. Our lab focuses on tissue-specific properties of cDC1 in lung tumours, focusing on the ...

For non-small cell lung cancer ... and a subsequent evaluation of a RAS(ON) inhibitor doublet with daraxonrasib. Based on a highly productive virtuous cycle between the preclinical and clinical ...

Adding immunotherapy to a new type of inhibitor that targets multiple forms of the cancer-causing gene mutation KRAS kept ...

Assessment of transfer entropy is useful for network analysis of cell signaling network providing information on the network topology and action points of genetic mutations and drug effect, thus will ...

The intrinsic factor of cell senescence, PCBP2, was identified by unlabeled quantitative proteomics, and its biological role in in vitro replication senescence of human bone marrow mesenchymal stromal ...

New research uncovers new insights into preventing chronic inflammation caused by aging-related zombie-like cells. In humans ...

Mechanistically, the compound induced cell cycle arrest: in SW-480 and Caco-2 cells, it halted progression at the S phase through the ATR/Chk1 pathway, while in HCT-116 cells, it caused arrest at ...

Several factors contribute to the RPSC RAS Cut Off 2024 for all the categories. However, these factors change every year. Some of these factors are listed below. Number of Test-Takers Categories ...

Jan. 28, 2025 — A team of stem cell scientists have successfully used embryonic stem cell engineering to create a bi-paternal mouse -- a mouse with two male parents -- that lived until adulthood.