Reduced receptor-mediated LDL endocytosis causing raised blood LDL cholesterol (LDL-C) is the main defect, but other abnormalities due to lack of LDL receptors include altered hepatic cholesterol ...

A new Drosophila collection of Parkinsonism models reveals early synaptic cholinergic projection neuron dysfunction, linking synaptic failure to later dopaminergic decline, highlighting a role for ...

Background Development of diffuse-type gastric cancer (DGC) starts with intramucosal lesions that are primarily composed of ...

Receptor pharmacology is the study of the interactions of receptors with drugs/pharmaceuticals and other xenobiotics. A basic tenet of receptor pharmacology is that a drug’s effect is directly ...

Next, we summarize clinical trials assessing the efficacy of antibodies targeting Claudin-6 or Claudin-18.2. Finally, emerging strategies for targeting Claudins, including Chimeric Antigen Receptor ...

Facundo’s lab studies B-cell biology and antibody responses, particularly B-cell receptor signaling dynamics ... the University of Göttingen where she worked on cell polarity and endocytosis in ...

In 2017, he established his own group at the Gregor Mendel Institute in Vienna. Research in his lab focusses on autophagy-mediated cellular quality control mechanisms. Claudio is a Group Leader at the ...