Prostate cancer is one of the most common malignancies in men globally. Hormonal therapies targeting the androgen–androgen receptor axis have significantly delayed disease progression. However, drug ...

Studies on the NMR methodology for characterizing the structure of polymers and biopolymers based on the understanding of the NMR chemical shift/structure correlation using solution-state and ...

Researchers have solved a mystery that has confounded scientists for 80 years: the crystal structure of the ...

Mitochondria are cell organelles surrounded by a double membrane. In addition to numerous essential functions in the ...

Can you imagine a life-saving molecule whose “twin” is a deadly poison? As surprising as it may seem, this chemical reality is known as “chirality”. Like a right hand and a left hand, two molecules ...

In this issue of Nature Chemical Biology, Challis and coworkers 1 present an alternative paradigm for natural-product discovery in which the 'chance' component is largely abated.

Hormone therapy for prostate cancer is typically initiated using drugs that lower serum testosterone, often in combination with competitive androgen receptor antagonists.

Thus, any one of a number of primary molecular events that alter androgen receptor activity could cause an increase in androgen receptor mRNA, suggesting a common final pathway for escape from ...