Pathway-focused metabolite ratio-based analysis of 49 tumor and 8 normal epithelial cell lines grown in their respective ...

The FDA has approved Emrelis for the treatment of adult patients with locally advanced or metastatic NSCLC with high c-Met protein overexpression.

This study identifies 53BP1 as an interaction partner of GMCL1 (a likely CUL3 substrate receptor). The study seeks to link this finding to regulation of the mitotic surveillance pathway and paclitaxel ...

To explore the mechanism of anti-leukemic activity of 2’F-araAC, cell cycle and apoptosis analyses were performed on P388 and L1210 cell lines. Results: It has been shown that the DNMTs activity was ...

Transwell assays also showed that Z-GS inhibited TNBC migration and invasion phenotypes. Our network pharmacology combined with RNA-sequencing analyses showed that Z-GS affected cell cycle and ...

Cells were treated with increasing concentrations of ferric ammonium citrate (FAC) to mimic iron overload in vitro. Treated cells were assessed for cell viability, cycling, apoptosis ... disrupted ...

Rising use of cell viability assays in evaluation of drug safety and efficacy, increasing use in quality control experiments, and rising focus on cell-based therapeutics to treat chronic illnesses are ...

Inc. Extensive research activities on expanding applications of drug-induced apoptosis assays have propelled the inclination of pharmaceutical manufacturers towards incorporating cell cycle ...

The experiment was repeated three times. Apoptosis and cell cycle arrest are two causes of cell growth inhibition (23, 24). The apoptosis assay was performed by flow cytometry using an Annexin ...

Cell proliferation was assessed with a real-time cell analyzer and MTT assay. Cell apoptosis, cell cycle distribution and ROS levels were measured using cytometry. Mitochondrial damage was ...

Nerviano conducts HCS assays to evaluate mechanisms of action of lead compounds affecting regulation of cell cycle or apoptosis. Cytostatic or cytotoxic effects are determined through specific ...