All of the updated Week 17 NFL lines are listed below, and SportsLine's advanced computer model has all the NFL betting advice and NFL predictions you need to make the best Week 17 NFL picks now.

Bills vs. Patriots has Buffalo favored by 14 points in the largest of the Week 16 NFL lines and one of the biggest NFL spreads of the season. Additionally, Bengals vs. Browns (+9.5, 46.5 ...