When Grey’s Anatomy premiered in 2005 ... This ends up being a point of contention between Meredith and Derek’s sister, Dr. Amelia Shepherd, in the following seasons.

Grey's Anatomy is surrounded by fan theories, but an assumption about Derek Shepherd is becoming more and more convincing.

When Grey's Anatomy took off as a cultural phenomenon in the mid-2000s, Patrick Dempsey's Dr. Derek Shepherd also swiftly became one of the biggest heartthrobs on television. Nicknamed "McDreamy ...

Thursday's episode was one of the ABC drama's most heartbreaking Did that really just happen on Grey’s Anatomy? In a shocking twist, the beloved character Dr. Derek Shepherd, aka McDreamy ...

Grey’s Anatomy is best known for exposing the ... She also mourned her brother, Dr. Derek Shepherd (Patrick Dempsey), on the show. While Amelia losing Derek was extremely hard for the ...

Is this the end of Dr. Derek Shepherd?! We hate to admit it, Grey's Anatomy fans, but things aren't looking too great for McDreamy in this special sneak peek from tonight's episode. While en route ...

Shonda Rhimes did not back down from her decision to kill off Patrick Dempsey’s Dr. Derek (McDreamy) Shepherd on “Grey’s Anatomy” to reporters on Tuesday and said it was all in the name of ...

"I'll be back before you know it," said hunky Dr. Derek Shepherd, flashing a smile as he walked away from wife Meredith Grey at the start of Thursday's Grey's Anatomy episode. But now we know ...

The Transformers villain Patrick Dempsey is a proud father, and he doesn't shy away from showing it!The 59-year-old recently ...

Patrick Dempsey as Dr. Derek Shepherd in the 'Grey's Anatomy' episode 'Map of You,' airdate Oct. 24, 2013 Fans may never recover from this one. Dr. Derek Shepherd (Patrick Dempsey) — a.k.a ...

her deep friendships and her enduring romance with Dr. Derek Shepherd. (SOUNDBITE OF TV SHOW, "GREY'S ANATOMY") POMPEO: (As Meredith Grey) Derek, I love you in a really, really big, pretend to ...