Retinoic acid receptor alpha (RARα) is a nuclear receptor with a central role in spermatogenesis. Genetic knockout studies in mice have shown that the lack of RARα leads to a complete absence of sperm ...

Researchers found that TEX38 and ZDHHC19 co-localize on the plasma membrane of spermatids and mediate S-palmitoylation of ARRDC5, a crucial protein for spermatogenesis. Disrupting either TEX38 or ...

Models of 3D chromatin dynamics and gene regulation on autosomes and sex chromosomes during spermatogenesis. Credit: Nature Structural & Molecular Biology (2025). DOI: 10.1038/s41594-025-01482-z ...

Cytoplasm removal in spermatogenesis.When TEX38 or ZDHHC19 is deficient, cytoplasm is not properly removed and sperm are folded. Credit: Masahito Ikawa "The results were striking," says Masahito ...

Supplements can offer some support for those too busy to incorporate all the necessary nutrients. The NHS and the UK Government Department of Health recommend that everyone in the UK take vitamin D ...

This valuable study presents data suggesting the critical roles of two ancient proteins, XAP5 and XAP5L, in regulating the transcriptional program of ciliogenesis during mouse spermatogenesis. The ...

Strengths: Knockout mouse models provided strong evidence to indicate that XAP5 and XAP5L are critical for spermatogenesis. RNA-seq and CUT & Tag are valuable sources to further explore their ...

circRNAs can act as a competitive endogenous RNA (ceRNA) to regulate gene expression by regulating the activity of miRNA (4), thereby participating in the biological processes of testicular ...

Although there are plenty of studies on the reproduction of turbot, the complete cytological process of spermatogenesis remains unclear. In this study, we investigated the submicroscopic structure of ...

Why are the human sex chromosomes called “X” and “Y,” while the other 22 chromosomes are identified only by numbers? The answer begins in the late 1800s, when insect gonad cells, whose large ...