HIF-2α is a subtype of the HIF. HIF-2α increases the expression of Superoxide Dismutase 2 (SOD2), an antioxidant enzyme that can reduce ROS (110). Chronic hypoxia from SAS causes an increase in ROS, ...
Roxadustat (FG-4592) is a new hypoxia-inducible factor prolyl hydroxylase (HIF-PHD ... in line with the upregulation of HIF-1α and its target genes of Bcl-2 and SOD2. Importantly, FG-4592 displayed ...
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