Understanding how molecular arrangements within crystals influence their thermal behavior is a fundamental question in solid-state chemistry. This topic is especially relevant in pharmaceuticals ...

Monosodium urate crystals dissolve and are eliminated from joints and soft tissues as serum uric acid levels drop below its saturating point (400 μmol/l). Time to crystal clearance relates to ...

Gout flares are associated with cardiovascular events. Treating gout to target serum urate levels prevents flares, but whether such treatment can also prevent cardiovascular events is unknown.

First-in-human data has demonstrated the feasibility and potential efficacy of targeting the intracellular immune checkpoint CISH in patients with heavily pretreated metastatic colorectal cancer. 1,2 ...

Crystals—from sugar and table salt to snowflakes and diamonds—don't always grow in a straightforward way. New York University researchers have captured this journey from amorphous blob to ...

Objective: Recent studies suggest that crystals of monosodium urate (MSU), deposited in joints of patients with acute gouty arthritis, activate the NACHT domain, leucine-rich repeat and pyrin ...

Gouty arthritis is caused by hyperuricemia, and it can develop even when the serum urate level is controlled. Methods to recognize and identify symptoms include polarization microscopy, X-ray imaging, ...

WASHINGTON — Different stages of gout treatment may call for different serum urate targets, with certain levels being better for dissolving or preventing monosodium urate crystals, according to ...

The artificial genes can build intracellular structures through a cascading sequence that builds self-assembling structures piece by piece.

Recent groundbreaking advances in the structural biology of the glucose transporter 9 (GLUT9) and urate transporter 1 (URAT1) have provided critical insights into the molecular mechanisms ...