Background: Monosodium urate (MSU) and calcium pyrophosphate dihydrate (CPPD) crystal-induced interleukin 1 β (IL1β) release contributes to inflammation in subcutaneous air pouch and peritoneal models ...

1 Introduction Gout is a metabolic disorder with hyperuricemia and urate crystal deposition followed by chronic inflammation and recurrent flares of acute arthritis. It is associated with increased ...

Objectives: To determine whether hypouricaemic treatment results in the disappearance of urate crystals from gouty joints and to define the time required. Methods: In 18 patients with monosodium urate ...

Membranes are crucial in permselective processes, such as water purification, gas sequestration, ion separation, membrane distillation and pervaporation, and energy conversion and storage. The ...

The investigational compound SAP-001 had a sustained effect on serum urate levels vs placebo, but not on gout flares in a Phase 2b study.

Gout patients who met a target serum urate level of < 360 μmol/L (6 mg/dL) within 12 months of treatment cut their risk for major cardiovascular events vs patients who did not.

Understanding how molecular arrangements within crystals influence their thermal behavior is a fundamental question in solid-state chemistry. This topic is especially relevant in pharmaceuticals ...