A study reveals a mechanism that controls B-lymphocyte maturation, with SIRT7 playing a critical role. This insight could lead to new treatments for B-cell Acute Lymphoblastic Leukaemia (B-ALL).

T-cell acute lymphoblastic leukemia (T-ALL) is a highly aggressive form of blood cancer that can occur in both children and ...

Helix–loop–helix (HLH) proteins are essential factors for lymphocyte development and function. One class of HLH proteins, the E-proteins, regulate many aspects of lymphocyte maturation ...

During lymphocyte maturation, each B cell and T cell acquires specific cell membrane surface receptors that allow them to "match up" with certain foreign antigens.

Calcium plays an essential role in lymphocyte activation and maturation but the exact effect on gene expression is not known. In April Nature Immunology Stefan Feske and colleagues from Harvard ...

B-cell Maturation and Homeostasis B lymphocytes arise from hematopoietic stem cells in the bone marrow. These cells mature independently of an antigen first into pro-B cells, then into pre-B cells ...

Effect of CD3δ Deficiency on Maturation of α/β and γ/δ T-Cell Lineages in Severe Combined Immunodeficiency This article has been corrected.

Interleukin-12 (IL-12) is a pleiotropic cytokine designated as a cytotoxic lymphocyte maturation factor and NK cell stimulator that interconnects innate and adaptive immunity. Studies in animal models ...

The thymus plays a key role in the body's immune response. It is here where the T lymphocytes or T cells, a major type of immune defence cells, mature. Different types of T cells, designated to ...

To fight off viral and bacterial invaders, immune cells known as lymphocytes generate antibodies that specifically recognize and bind to these invaders, neutralizing them directly or marking them ...