thecardiologyadvisor.com29d
MEK Inhibition Beneficial for Children With Subset of Severe Hypertrophic Cardiomyopathy
The decrease in mortality, morbidity were seen with trametinib for children with RASopathy-associated hypertrophic cardiomyopathy. HealthDay News — For children with severe hypertrophic cardiomyopathy ...
Frontiers3mon
Activation of MEK‐ERK‐c‐MYC signaling pathway promotes splenic M2-like macrophage polarization to inhibit PHcH-liver cirrhosis
Methods: RNAseq, protein chip, western blot, and chip-seq were performed on macrophages and the in vitro MEK inhibitor rafametinib was used. Carbon tetrachloride and thioacetamide induced mouse ...
Frontiers2y
Design, Synthesis, and Antileukemic Evaluation of a Novel Mikanolide Derivative Through the Ras/Raf/MEK/ERK Pathway
However, a bioactive mikanolide derivative, 3g, was found with potent antileukemic activity, through the Ras/Raf/MEK/ERK pathway. It can arrest the cell cycle by inhibiting phosphorylation of CDC25C, ...