In this application note, explore how scientists can couple a serum-free medium with a xeno-free serum replacement to effectively culture functional monocyte-derived dendritic cells and macrophages.

More information: Alexander Simonis et al, Persistent epigenetic memory of SARS-CoV-2 mRNA vaccination in monocyte-derived macrophages, Molecular Systems Biology (2025). DOI: 10.1038/s44320-025 ...

The study 'Persistent epigenetic memory of SARS-CoV-2 mRNA vaccination in monocyte-derived macrophages' led by Professor Dr Jan Rybniker, who heads the Division of Infectious Diseases at ...

This study provides proof-of-principle data for the use of trained immunity to modulate macrophage interactions with tumours. The study makes a valuable contribution to the field of trained immunity.

The monocyte effect. Monocytes/macrophages (promonocytes in the bone marrow, circulating monocytes, tissue macrophages) play a major role in the induction and regulation of immune reactivity.

Johnson & Johnson announces positive results from phase 3b APEX study of Tremfya to treat adults living with active psoriatic arthritis: Spring House, Pennsylvania Monday, April 7 ...

Pulmonary sarcoidosis is a lung disease characterized by granulomas-tiny clumps of immune cells that form in response to ...

Here we show that SARS-CoV-2 mRNA vaccination significantly establishes histone H3 lysine 27 acetylation (H3K27ac) at promoters of human monocyte-derived macrophages, suggesting epigenetic memory.

Pulmonary sarcoidosis is a lung disease characterized by granulomas -- tiny clumps of immune cells that form in response to inflammation. It's the most inflammatory of the interstitial lung diseases ...

This diagram illustrates the role of macrophage ATF6 in orthodontic tooth movement. When corticotomy is applied, monocytes are recruited to the bone, where they differentiate into pro-inflammatory ...