Patients with systemic sclerosis and calcinosis cutis may have a higher tendency for bone-resorbing cell activity, suggesting ...

Historical trends and future projections of the number of people with overweight and obesity suggest alarming parallel ...

TNFRSF11A encodes the receptor activator of NFκB (RANK), which is critical for normal osteoclast formation; genetic variants in this gene result in familial expansile osteolysis, a Paget-disease ...

Osteoporosis, a condition leading to fragile bones, often progresses without symptoms, making it a “silent disease.” Essential measures include weight-bearing exercises, a diet rich in calcium and ...

Jan. 21, 2025 — The discovery of a family with sequence similarity 102 member A (Fam102a) protein as a novel bone remodeling factor that regulates both osteoclast and osteoblast differentiation ...

In space, osteoclasts seem to be working overtime with that team of researchers finding that the space-bound fish had increased osteoclast activity and a significant reduction in bone mineral density.

Department of Hygiene Toxicology, School of Public Health, Zunyi Medical University, Zunyi, Guizhou 563000, China Key Laboratory of Maternal and Child Health and Exposure Science, Guizhou Provincial ...

Lower back pain is something most people will deal with at some point—around 8 out of 10 people, in fact. It can be mild or ...

While many treatments focus on easing pain for the short term, a new study suggests that a drug already in use for other purposes might help treat one of the root causes of lower back pain—especially ...

Researchers have found in a new research that Metformin shows promise in promoting periodontal tissue repair following ...

Studies suggest that by acting as a decoy receptor for myostatin—a protein believed to inhibit muscular tissue development—ACE-031 may offer novel avenues for research into wasting disorders that ...

In bone, PTH stimulates osteoclast activity, leading to bone demineralization and the release of calcium and phosphate. In the kidneys, PTH stimulates calcium reabsorption and phosphate excretion, ...