While several scientific reports have revealed the distinct regulatory mechanisms of osteoclast and osteoblast differentiation, little is known about the common factors that influence the ...

The discovery of a family with sequence similarity 102 member A (Fam102a) protein as a novel bone remodeling factor that regulates both osteoclast and osteoblast differentiation can aid the ...

To identify novel bone remodeling factors and related mechanisms involved in both osteoclast and osteoblast differentiation, a team of researchers led by Professor Tomoki Nakashima from the ...

Objectives Metabolic changes are crucially involved in osteoclast development and may contribute to bone degradation in rheumatoid arthritis (RA). The enzyme aconitate decarboxylase 1 (Acod1) is known ...

In most primary and metastatic malignant tumors, bone destruction can promote cancer progression, which is closely related to osteoclast activation and the imbalance between osteoblasts and ...

So, the effect of black tea extract (BTE) and thearubigins (TRs) on osteoporosis in rats and osteoclast formation in vitro were investigated. Methods: In vivo, ovariectomized (OVX) rats were used to ...

A substantial and persuasive body of data now exists that supports the view that integrin alpha V beta 3 plays a critical part in activated macrophage dependent inflammation, osteoclast development, ...

Endocrinology is the branch of medicine that deals with disorders of the endocrine system. Optical measurements through the skin are challenging because they usually represent averages across the ...

Feb. 11, 2025 — A new study has discovered in mouse models that genes associated with repairing mismatched DNA are critical in eliciting damages to neurons that are ... 'Junk' RNA Segments Play ...