This month's cover highlights the article Nup358 restricts ER-mitochondria connectivity by modulating mTORC2/Akt/GSK3β signalling by Joseph, Misha Kalarikkal and colleagues. The image shows a human ...

Panelists discuss exciting updates on Bruton tyrosine kinase (BTK) inhibitors from the 2024 American Society of Hematology (ASH) Annual Meeting and Exposition, highlighting emerging data that may ...

This undercurrent of anxiety might explain why so many “PTO hacks” for maximize your time off go viral every year. But many of them boil down to this simple yet sage advice: Strategically schedule ...

This crystal structure of nearly full-length human cGMP-dependent protein kinase Iβ (PKG Iβ) provides convincing new insights into how in the absence of cGMP the activity of the catalytic domain is ...

Central to the sensing of DSBs is the ATM (Ataxia-telangiectasia mutated) kinase, which belongs to the phosphatidylinositol 3-kinase-related protein kinase (PIKK) family. In response to DSBs, ATM is ...

Short linear motifs (SLiMs) are functional stretches of protein sequence that are of crucial importance for numerous biological processes by mediating protein–protein interactions. These motifs often ...

Prf forms homodimers that bridge Pto to Fen, or possibly another Pto-family kinase. AvrPto targets Pto and recognition results in a conformational change that activates Prf signaling. AvrPtoB is an E3 ...