About Non-Small Cell Lung Cancer and RAS Mutations More than 197,000 people are diagnosed with non-small cell lung cancer (NSCLC) in the U.S. each year. 1 Despite treatment advancements, NSCLC remains ...

Introduction Non-small cell lung cancer (NSCLC) is the predominant lung cancer subtype in the United States, constituting approximately 85% of all diagnosed cases (1, 2). Two frequently altered driver ...

Cells were treated with 0.1-100 µM of RAS-MAPK inhibitors alone or with gemcitabine and the 50% cell viability- inhibition values were obtained from dose-response curves at 96 hours time-point.

The EGF signaling pathway regulates cell growth, proliferation, differentiation, and survival through the activation of EGFR and downstream cascades like RAS/RAF/MEK/ERK and PI3K/AKT.

The awe-inspiring process of cell division can turn a fertilized egg into a baby – or a cancerous cell into a malignant tumor. With so much at stake, nature keeps it tightly controlled in a process ...

Dubai: A full-scale battery cell manufacturing plant in the UAE? And that too a gigafactory? Statevolt plans to build such a facility in Ras Al Khaimah, with a planned capital outlay of $3.2 billion.

Cell cycle arrest (CCA) is seen as a prime candidate for effective cancer therapy. This mechanism can help researchers to create new treatments to target cancer cells at particular stages of the cell ...

Temporal bulk and single-cell RNAseq data from 4F-transduced human iPSC-derived CMs (hiPS-CMs) or P7 neonatal mouse CMs (NMCM) indicated a transient downregulation of contractile genes during the ...

Abstract 12469: Ras-Related Associated With Diabetes (RRAD) Regulates Cardiomyocyte Response to Cell Cycle Stimulation Riham Abouleisa, Abou bakr M Salama, Jessica Miller, Fareeha Abdulwali, dana ...

Penn Medicine on Nov. 13, 2021. Credit: Riley Guggenhime Researchers at the Perelman School of Medicine have discovered a new type of cell, the respiratory airway secretory cell in the lung, which ...

In normal health, Ras signaling is central to the regulation of intracellular signaling networks involved in cell proliferation, growth and survival. Like many cellular signaling pathways, however, ...

The RAS GTPases act as molecular switches, alternating between an inactive GDP‐bound state and an active GTP‐bound state. In the active state, RAS proteins have a greatly increased binding affinity ...