Ras-MEK directs pre–B cell differentiation. To better understand how proliferation is regulated during B lymphopoiesis, we sought to identify the specific signaling pathways that suppress Ccnd3 ...

The Ras oncogene transforms cultured murine fibroblasts into malignant, focus-forming cells, whose lack of contact inhibition is evidenced by high saturation densities. In order to investigate the ...

Oncogenic MYC and RAS, for example, induce p16, which leads to cell-cycle arrest and senescence. 13,14 The CIP/KIP CDK inhibitors (p21, p27, and p57), which were initially described as inhibitors of ...

Phase III Trial of Two Versus Four Additional Cycles in Patients Who Are Nonprogressive After Two Cycles of Platinum-Based Chemotherapy in Non–Small-Cell Lung Cancer p53 and RAS are multifunctional ...

Ras GTPase family proteins have a role in a number of processes including cell cycle progression, growth, migration, cytoskeletal changes, apoptosis, and senescence. Ras mutations ...

Bochum biophysicists in collaboration with the MPI Dortmund have for the first time measured the orientation of the Ras protein bound to the cell membrane. The RUB team combined the use of three ...

In normal health, Ras signaling is central to the regulation of intracellular signaling networks involved in cell proliferation, growth and survival. Like many cellular signaling pathways, however, ...

The Ras protein switches the cell growth off by detaching a phosphate group from the small bound guanosine triphosphate, GTP for short. GTP has three interlinked phosphate groups.

Penn Medicine on Nov. 13, 2021. Credit: Riley Guggenhime Researchers at the Perelman School of Medicine have discovered a new type of cell, the respiratory airway secretory cell in the lung, which ...

About Non-Small Cell Lung Cancer and RAS MutationsMore than 197,000 people are diagnosed with non-small cell lung cancer (NSCLC) in the U.S. each year.1 Despite treatment advancements, ...

About Non-Small Cell Lung Cancer and RAS Mutations More than 197,000 people are diagnosed with non-small cell lung cancer (NSCLC) in the U.S. each year. 1 Despite treatment advancements, ...