Three people were injured Monday night in a wrong-way crash on Interstate 40 near the Hammond Road exit in Raleigh.

Traffic was at a standstill and backed up for miles in Tennessee and North Carolina on both sides of the interstate.

A police chase on Interstate 40 near Aviation Parkway ended in the arrest of 22-year-old Lazarus Jaire Reid, charged with ...

Officials with the Arkansas State Police said that Interstate 40 eastbound at Mile Markers 159 and 160 is shutdown due to ...

A man is facing charges after police said he drove on the wrong side of a busy interstate in Raleigh on Monday night, leading ...

A 17-year-old Nashville teen was killed in a three-vehicle crash on Interstate 40 West near Spence Lane.Police say the car he ...

The North Carolina State Highway Patrol said a single tractor-trailer carrying fuel exploded on I-40 after a crash involving ...

A man has been accused of driving the wrong way on Interstate 40 in Winston-Salem and hitting a police cruiser. This happened ...

A Nashville teenager has been identified as the victim killed in a three-vehicle crash on Interstate 40 West overnight.

KNOXVILLE, Tenn. — Every day, more than 26,000 vehicles travel through the Pigeon River Gorge, a winding, mountainous 28-mile stretch of Interstate 40 that cuts through the Great Smoky Mountains.

The North Carolina Department of Transportation (NCDOT) is working on ways to reduce human-wildlife collisions.